Correction: potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis
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چکیده
* Correspondence: [email protected] Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, 200 1st Street, Rochester, MN 55905, USA Department of Biomedical Engineering, Mayo Clinic Rochester, 200 1st Street, Rochester, MN 55905, USA Full list of author information is available at the end of the article Figure 1 Immunoblot analysis of CLL B cells exposed to gold particles (Au) alone, AbVF alone at 5 and 25 μg/ml and AUAbVF at 5 and 25 μg/ml. Note the prominent PARP cleavage, decrease in caspase 3, Mcl-1 and moderate change in Bcl-2 for CLL B cells treated with Au-AbVF at 25 μg/ml. These changes were noted but less evident for Au-AbVF at the 5 μg/ml dose.
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Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis
B-Chronic Lymphocytic Leukemia (CLL) is an incurable disease predominantly characterized by apoptosis resistance. We have previously described a VEGF signaling pathway that generates apoptosis resistance in CLL B cells. We found induction of significantly more apoptosis in CLL B cells by co-culture with an anti-VEGF antibody. To increase the efficacy of these agents in CLL therapy we have focus...
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